Ghiscar can refer to:
- Ghiscar (region): a region located in south-central Essos, on the southeast of Slaver's Bay.
- Ghiscar (dragon): a dragon.
It is also related to:
- Ghiscari: the people native to Ghiscar and the nearby areas, now a mongrel race.
- Ghiscari Empire: a fallen empire established on the region.
- Old Ghis: the now-ruined capital city of the Empire.
- Old Ghiscari: the language of the defunct Empire.
- New Ghis: a city located on an island south of the Ghiscari Strait.