Considering her absence from the family tree (per the article), and lines from episode 202 stating his wife giving only stillborns (as well as her general absence, and of Patchface, alas), it would seem she has been effetely written out from the series.. 22.214.171.124 00:45, April 10, 2012 (UTC)
I thought that Melisandre was specifically saying that Selyse had stillborn sons thus leaving the door open for Shireen.--Opark 77 00:51, April 10, 2012 (UTC)
Melisandre says "no heirs, only stillborns, only death" or pretty much that.--Gonzalo84 04:50, April 10, 2012 (UTC)
- She says "And she has given you nothing. No sons. Only stillborns. Only death." Stannis then gives himself to her saying "a son", not a heir or a child.
Second Cousin (noun) the child of a first cousin of either of one's parents 
"Second Cousins" - the children of two first cousins. (Wikipedia - Cousins).
Melessa Florent and Selyse Florent are first cousins. Samwell is Melessa's child, Shireen is Selyse's child. Thus, they are clearly second cousins.--The Dragon Demands (talk) 14:01, July 15, 2013 (UTC)
Too early to say she is dead
Until we see the charred remains of Shireen, we cannae assume that she is dead. Twice I have predicted the survival of characters that were seemingly killed off (Theon because if Luwin can survive a sword to the chess, then Theon can live a whack to the noggin; and Davos after a blind guess).
Of all characters, Shireen Baratheon is the most likely to survive being burnt at the stake. Shireen is a Baratheon, therefor she has the blood of a dragon. Heck, with that Grayscale of hers she even looks like one! The last Alterac (talk) 12:10, June 10, 2015 (UTC)
As seen with Viserys (molten gold), Aerion Brightflame (drank wildfire and burned to death), and several Targaryens during the Dance of the Dragons, Targaryens aren't actually immune to fire at all. They have a slightly higher heat tolerance than other people, but actual flame? No.--The Dragon Demands (talk) 13:30, June 10, 2015 (UTC)